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Literal equivalents for 'original design' are limited only by time spent with a thesaurus and the context in which the phrase is being used.
This question being under the Religion and Spirituality section leads me to believe that this may be in reference to the term 'Intelligent Design'. An alternative phrase for 'Intelligent Design' would be Creationism.
The fallaciously labeled 'scientific theory' for the teleological proof of the existence of god--and in turn the divine nature of the universe--can be referred to by any phrase that denotes any theological concept [specific to Christianity¹] that claims [or in certain cases 'implies'] God to be the architect, designer, and/or initiator of aspects of the universe relating to it's creation and to living things².
¹"...the majority of principal intelligent design advocates are publicly religious Christians."
http://en.wikipedia.org/wiki/Intelligent_design#Movement
A point that should be made about the God of Intelegent Design being the 'Christian God' is that this removes those Christian denominations that have tendencies towards henotheistic views.
² An interesting area of inquiry regarding the application of Intelegent Design is the qualifications and characteristics of 'living things'. In specific, the differences between the scientific and judeo-christian requirements.
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