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G6PD is an enzyme of the hexose monophosphate (HMP) shunt pathway, which metabolizes 5% to 10% of the glucose used by red blood cells (RBC). It catalyzes oxidation of glucose-6-phosphate (G6P) to 6-phosphogluconolactone with simultaneous reduction of nicotinamide adenine dinucleotide phosphate (NADP) to reduced NADP (NADPH). The latter is an important reducing compound for conversion of oxidized glutathione (GSSG) to glutathione (GSH) which protects red cells against free radical (eg, superoxide anion) oxidative injury. Individuals with G6PD deficiency, especially when exposed tocontraindicated drugs and foods, are unable to maintain adequate levels of reduced glutathione in their RBCs leading to oxidation of hemoglobin sulfhydryl groups.Hemoglobin precipitates within RBCs, forming Heinz bodies. These membrane-bound inclusions lead to mechanical trapping of affected red cells in splenic capillaries resulting in hemolysis.Both intravascular and extravascular hemolysis occurs in these patients. If these contraindicated substances are strictly avoided, a person with G6PD can live a long healthy life.
This enzymopathy affects 10% of the population, many of which don't know they have it, or have been misdiagnosed.
(This information was copied with permission from g6pddeficiency.org.)
Wiki User
∙ 13y ago
Wiki User
∙ 13y agoGlucose 6 phosphate is regenerated at the end of oxidative phase of pentose phosphate pathway- how it happens explain
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Why the patient that have g6pd deficient cannot take paracetamol and why?
Can you be around fire works if you have g6pd
Hazelnut avoided in g6pd defficiency?
No
Is there a genetic test for deficiency of G6PD?
Yes. Direct DNA testing and sequencing of the G6PD gene are possible, and there is also a fast an inexpensive test called the "Beutler flourescent spot test" that can be performed on the blood of a patient suspected of having G6PD.
What are the symptoms of G6PD?
The most significant consequence of this disorder is hemolytic anemia, which is usually episodic, but the vast majority of people with G6PD deficiency have no symptoms.
Can you take tramadol with g6pd?
Tramadol is not on the list of contraindicated drugs for those with G6PD. Remember to always tell your doctor and pharmacist that you are G6PD Deficient and have them verify that the medicine is allowable for your use. An answer of 'probably' isn't really acceptable from a doctor making $300 an hour ;)
Can women get G6PD deficiency?
Yes, women can have G6PD deficiency. The condition is inherited in an X-linked recessive pattern, which means that females need to inherit two copies of the defective gene, one from each parent, to have the full-blown deficiency. However, women who inherit one copy of the gene can still be carriers and may pass the gene on to their children.
What is a normal range of G6PD?
5-13
Can terbinafine be taken by a G6PD patient?
yes
Does paracetamol produce hemolysis in patients with G6PD?
no
What color tube is used for G6PD?
lavender
Ano ang mga bawal sa may sakit na G6PD?
Ano po bawal Na karne SA may g6pd
What does the acronym G6PD stand for?
The acronym G6PD stands for glucose-6-phosphate dehydrogenase. It is sometimes referred to as G6PDH and is an enzyme in the pentose phosphate pathway.
