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Modic changes, a common observation in MR imaging, are signal intensity changes in vertebral body marrow, adjacent to the endplates of degenerative discs.
Michael T. Modic, MD, professor of radiology and neurology at Case Western in Cleveland, wrote about these changes in the journal Radiology in 1988, and his name has been associated with these changes ever since.
Modic changes take 3 main forms:
Type I
· Decreased signal on T1, and increased signal on T2.
· Represents marrow edema.
· Associated with an acute process.
· Histological examination shows disruption and fissuring of the endplate and vascularized fibrous tissues within the adjacent marrow
Type II - the most common type
· Increased signal on T1, and isointense or slightly hyperintense signal on T2.
· Represents fatty degeneration of subchondral marrow.
· Associated with a chronic process.
· Histological examination shows endplate disruption with yellow marrow replacement in the adjacent vertebral body.
Type I changes convert to Type II changes with time, while Type II changes seem to remain stable.
Type III
· Decreased signal on both T1 and T2.
· Correlate with extensive bony sclerosis on plain radiographs.
· Histological examination shows dense woven bone; hence, no marrow to produce MRI signal.
MODIC CHANGES on MRI
T1
T2
Significance
TYPE 1
¯
Edema
TYPE II
® (or slight)
Fatty Degeneration
TYPE III
¯
¯
Bony Sclerosis
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What is Modic-2 degenerative endplate changes?
Modic changes, a common observation in MR imaging, are signal intensity changes in vertebral body marrow, adjacent to the endplates of degenerative discs.Michael T. Modic, MD, professor of radiology and neurology at Case Western in Cleveland, wrote about these changes in the journal Radiology in 1988, and his name has been associated with these changes ever since.Modic changes take 3 main forms:Type I· Decreased signal on T1, and increased signal on T2.· Represents marrow edema.· Associated with an acute process.· Histological examination shows disruption and fissuring of the endplate and vascularized fibrous tissues within the adjacent marrowType II - the most common type· Increased signal on T1, and isointense or slightly hyperintense signal on T2.· Represents fatty degeneration of subchondral marrow.· Associated with a chronic process.· Histological examination shows endplate disruption with yellow marrow replacement in the adjacent vertebral body.Type I changes convert to Type II changes with time, while Type II changes seem to remain stable.Type III· Decreased signal on both T1 and T2.· Correlate with extensive bony sclerosis on plain radiographs.· Histological examination shows dense woven bone; hence, no marrow to produce MRI signal.MODIC CHANGES on MRIT1T2SignificanceTYPE 1¯­EdemaTYPE II­® (or slight­)Fatty DegenerationTYPE III¯¯Bony Sclerosis
Spine type 2 modic?
Modic type 2 changes refer to a specific type of bone marrow edema seen on MRI, typically associated with degenerative disc disease. These changes indicate an increase in fatty marrow and are often found in the vertebrae adjacent to degenerated intervertebral discs. While Modic type 2 changes can be asymptomatic, they are sometimes linked to chronic low back pain. Their clinical significance is still debated, and they may reflect underlying disc degeneration rather than direct pain causation.
How do astronauts and cosmonauts combat the degenerative effects of microgravity experienced on the International Space Station?
excersising 2 hours a day
What is 2 types of changes?
These are physical and chemical changes.
What does degenerative mean?
Adj. 1. degenerative - (of illness) marked by gradual deterioration of organs and cells along with loss of function; "degenerative diseases of old age" de·gen·er·a·tion (d-jn-rshn) n.1. The process of degenerating.2. The state of being degenerate.3. Medicine Gradual deterioration of specific tissues, cells, or organs with corresponding impairment or loss of function, caused by injury, disease, or aging.4. Biology The evolutionary decline or loss of a function, characteristic, or structure in an organism or a species.5. Electronics Loss of or gain in power in an amplifier caused by unintentional negative feedback.Noun 1. degeneration - the process of declining from a higher to a lower level of effective power or vitality or essential quality 2. degeneration - the state of being degenerate in mental or moral qualities 3.degeneration - passing from a more complex to a simpler biological form
Will the degenerative disc disease become a crippling condition Will you end up in a wheelchair?
Degenerative disc disease is not a disability. It is a disc problem and can be easily cured with the help of proper and timely treatment. Our spinal cord protects the nerves that send messages to the brain. It is made up of a series of connected bones or vertebrae. These vertebrae are stacked on top of each other forming an ‘S’ shape with the curve being the most at the neck and in the lower back. Each vertebra has a disc between them which acts as a shock absorber. As we grow older, the vertebrae in our spine tend to dry up and harden. This creates friction between the bones leading to several painful spinal problems such as Spinal Stenosis and Spinal Osteoarthritis. Problems arising from the natural aging of the spine are known as degenerative disc disease. Lifestyle changes, physical therapy, and medication help degenerative discs to some extent. However, if these fail spine fixation treatment may be considered. Ranka Hospital, Pune provides treatment for disc problems.
One of the 2 major degenerative disorders of the brain associated with nerotransmitter?
Alzheimer's disease is one of the major degenerative disorders of the brain associated with neurotransmitter imbalances, particularly acetylcholine. The other major disorder is Parkinson's disease, which is characterized by a deficiency of dopamine. Both conditions result in significant neurological and cognitive impairments.
What is the answer to 2 plus 3A plus 9A?
2 + 3A + 9A = 2 + 12AThe numerical value depends on the value of 'A'.It changes whenever 'A' changes.
What are 2 changes in warfare that occurred in ww1?
There are very many changes, but the 2 primary are the use of airplanes and machine guns
What 2 changes make up the water cycle?
The 2 changes include:evaporation , condensation. These make up the water cycle.
How many syllables are in the word changes?
2
What does 2x plus 2 equal?
That completely depends on the value of 'x', and whenever the value of 'x' changes, [ 2x + 2 ] also changes immediately.
