There are 557 English words starting 'u' - further letters needed to answer question
unscrew
uranium
A word that starts with A and ends with U: apercu.
A six letter word that starts with U is upward.
A word that starts with U and ends with G: understanding.
A word that starts with E and ends with U: ecru.
One word that starts with U and ends in E is "unique."
Any word that starts with the letter 'U' elsewhere.
uvula
Urethra
"up"
umbrella