sjogrens
An positive ANA (antinuclear antibody) means that you make antibodies that attack the circulating debris of the nucleii of your own cells that have died. A titer of 320 means that your blood had to be diluted320 times before they got a sample that had no antinuclear antibody. Typically the numbers are 40, 80, 160, 320, 640, and so on. Lupus presents a speckled pattern, not a nucleolar pattern. 10 million Americans have a positive ANA. Only 1.5 million have lupus. Many people have a positive ANA and no active disease of any kind. Unless you are having some kind of symptoms, don't be overly concerned.
A positive ANA (anitnuclear antibody) test means that the person makes antibodies against the nucleus of their own cells. All cells live for a while and then die. When they die, they break down in the blood. The antinuclear antibodies think that the debris from the nucleus is a germ that shouldbe destroyed. This is not normal. 10 million Americans have a positive ANA. 1.5 million have lupus. 2-3 percent of people with lupus will have a negative ANA. The pattern that shows up under when the cells are treated with immunofluorescent dye is more important than the fact that the test is postive. Lupus will cause a speckeld pattern. The ANA test is a titer. This means the number is how many times a sample of blood had to be diluted to come up with a sample that has no antinuclear antibodies in it. Typically the numbers will be 40, 80, 160, 320, 640 etc. Many people have a positive ANA and don't have any active disease. The older a person gets, the more likely they are to test postive.
A positive ANA (anitnuclear antibody) test means that the person makes antibodies against the nucleus of their own cells. All cells live for a while and then die. When they die, they break down in the blood. The antinuclear antibodies think that the debris from the nucleus is a germ that shouldbe destroyed. This is not normal. 10 million Americans have a positive ANA. 1.5 million have lupus. 2-3 percent of people with lupus will have a negative ANA. The pattern that shows up under when the cells are treated with immunofluorescent dye is more important than the fact that the test is postive. Lupus will cause a speckeld pattern. The ANA test is a titer. This means the number is how many times a sample of blood had to be diluted to come up with a sample that has no antinuclear antibodies in it. Typically the numbers will be 40, 80, 160, 320, 640 etc. Many people have a positive ANA and don't have any active disease. The older a person gets, the more likely they are to test postive.
Having an ANA (antinuclear antibody) pattern that is homogeneous with a flag of A typically indicates the presence of antibodies that bind to multiple components of the cell nucleus in a uniform or homogenous pattern. This pattern is often associated with autoimmune diseases such as systemic lupus erythematosus (SLE). The presence of this pattern can help healthcare providers in diagnosing and monitoring autoimmune conditions. Further testing and clinical evaluation are usually necessary to determine the specific autoimmune disease present.
A positive ANA (anitnuclear antibody) test means that the person makes antibodies against the nucleus of their own cells. All cells live for a while and then die. When they die, they break down in the blood. The antinuclear antibodies think that the debris from the nucleus is a germ that shouldbe destroyed. This is not normal. 10 million Americans have a positive ANA. 1.5 million have lupus. 2-3 percent of people with lupus will have a negative ANA. The pattern that shows up under when the cells are treated with immunofluorescent dye is more important than the fact that the test is postive. Lupus will cause a speckeld pattern. The ANA test is a titer. This means the number is how many times a sample of blood had to be diluted to come up with a sample that has no antinuclear antibodies in it. Typically the numbers will be 40, 80, 160, 320, 640 etc. Many people have a positive ANA and don't have any active disease. The older a person gets, the more likely they are to test postive.
ANA positive refers to the presence of antinuclear antibodies in the blood, which can indicate autoimmune diseases, such as lupus or rheumatoid arthritis. A speckled pattern is one of the various patterns observed in ANA testing under a microscope, characterized by small, scattered spots. This pattern is often associated with several autoimmune conditions but is not specific to any one disease. Further testing and clinical correlation are usually necessary to determine the underlying cause of the ANA positivity.
Cytoplasmic fluorescence in an antinuclear antibody (ANA) test indicates the presence of antibodies targeting components within the cell's cytoplasm, the gel-like substance inside the cell surrounding the nucleus. This pattern can be associated with certain autoimmune conditions, including autoimmune hepatitis and systemic lupus erythematosus. Further evaluation by a healthcare provider is usually needed to determine the significance of this finding in the context of the patient's overall health.
ANA stands for antinuclear antibodies. About 10 million Americans have them. Many have no disease. The older you are, the more likely you are to have a positive ANA. The ANA test is a titer. The result is the number of times ones blood must be diluted in order to come up with a sample that has no autoantibodies. The autoantibodies are then tested with immunofluorescence. The resulting pattern helps determine the type of disease.
The ANA titer is the number of times the blood sample has to be diluted before a sample remains that has no antinuclear antibodies. The first dilution is 1:40, then 1:80, then 1:160, then 1:320. The ANA number does not correlate to the level of disease activity. Many people have a positive ANA and no disease at all. In lupus, the immunofluorscent pattern is of more significance than the titer. A speckeld pattern points to the likelihood of lupus.
This is from a web.. i just got a positive ANA test myself, been researching like crazy to figure out what it could be..http://arthritis.about.com/od/diagnostic/a/ana.htmTypes of AntibodiesIn order to understand the ANA (antinuclear antibody) test, it is first important to understand different types of antibodies.Antibodies are proteins, produced by white blood cells, which normally circulate in the blood to defend against foreign invaders such as bacteria, viruses, and toxins.Autoantibodies, instead of acting against foreign invaders as normal antibodies do, attack the body's own cells.http://www.labtestsonline.org/understanding/analytes/ana/test.html#whatANA shows up on indirect immunofluorescence as fluorescent patterns in cells that are fixed to a slide that is evaluated under a microscope. Different patterns are associated with a variety of autoimmune disorders. Some of the more common patterns include:Homogenous (diffuse) - associated with SLE and mixed connective tissue diseaseSpeckled - associated with SLE, Sjogren's syndrome, scleroderma, polymyositis, rheumatoid arthritis, and mixed connective tissue diseaseNucleolar - associated with scleroderma and polymyositisOutline pattern (peripheral) -associated with SLE
No. 98% of people with lupus have a positive ANA with a speckled pattern. People with rheumatoid arthritis will have a positive rheumatoid factor and possible a positive ANA but with a different pattern.
Lupus presents with a speckled pattern.