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One disease of cattle caused by a prion is BSE (Bovine Spongiform Encephalopathy) aka Mad Cow Disease
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What are importance of prions?
PrionsA prion is an infectious protein that is misfolded. These proteins can aggregate in the brain and other neural tissue, forming amyloids. Diseases associated with prions include bovine spongiform encephalopathy (mad cow disease), scrapie, kuru, chronic wasting disease, and Creutzfeldt-Jakob disease. Prions are still poorly understood by researchers, and prion diseases (transmissible spongiform encephalopathies) remain untreatable.
Evidence that prions were responsible for mad cow disease?
At one time, cattle were fed the unwanted parts of ground up sheep. Some of those cows became infected with mad cow disease. Mad cow disease spread to humans. Cattle were also fed parts of ground up cow parts, cows eating ground up cattle were infected with that disease. The breakthrough came in New Guinea. There, women and children would eat the brains of dead people. Men would not. Women and children would catch a disease similar to mad cow disease. Men would not. That made it obvious that the disease came from something common to women and children and not to men. Since they behaved the same as nearby groups except for eating the brains of dead people, that had to be the difference. The only difference in the brains of the dead people with mad cow disease and those without mad cow disease was the prions. This was then tested in England where mad cow disease was common. The only difference between cows with mad cow disease and those without mad cow disease were the same prions. The people with mad cow disease had the same prions in their brains.
Why are prions unlike any other infectious disease?
They contain only protein and no nucleic acids
What is an aberrant protein?
aberrant proteins are prions which lead to infectious disease.
Can you give me all the information known about Prions?
Prions • Proteinaceous infectious agents (PrP) • Prions are misfolded proteins Diseases caused by prions: • spongiform encephalopothies • BSE (Bovine Spongiform Encephalopathy, aka Mad Cow Disease) • CJD (Creutzfeldt-Jakob disease) • kuru • scrapie in sheep Prions are only destroyed by: • incineration • autoclaving in 1N NaOH
What is prions?
PrionsA prion is an infectious protein that is misfolded. These proteins can aggregate in the brain and other neural tissue, forming amyloids. Diseases associated with prions include bovine spongiform encephalopathy (mad cow disease), scrapie, kuru, chronic wasting disease, and Creutzfeldt-Jakob disease. Prions are still poorly understood by researchers, and prion diseases (transmissible spongiform encephalopathies) remain untreatable.
What are importance of prions?
PrionsA prion is an infectious protein that is misfolded. These proteins can aggregate in the brain and other neural tissue, forming amyloids. Diseases associated with prions include bovine spongiform encephalopathy (mad cow disease), scrapie, kuru, chronic wasting disease, and Creutzfeldt-Jakob disease. Prions are still poorly understood by researchers, and prion diseases (transmissible spongiform encephalopathies) remain untreatable.
Evidence that prions were responsible for mad cow disease?
At one time, cattle were fed the unwanted parts of ground up sheep. Some of those cows became infected with mad cow disease. Mad cow disease spread to humans. Cattle were also fed parts of ground up cow parts, cows eating ground up cattle were infected with that disease. The breakthrough came in New Guinea. There, women and children would eat the brains of dead people. Men would not. Women and children would catch a disease similar to mad cow disease. Men would not. That made it obvious that the disease came from something common to women and children and not to men. Since they behaved the same as nearby groups except for eating the brains of dead people, that had to be the difference. The only difference in the brains of the dead people with mad cow disease and those without mad cow disease was the prions. This was then tested in England where mad cow disease was common. The only difference between cows with mad cow disease and those without mad cow disease were the same prions. The people with mad cow disease had the same prions in their brains.
What is the likely causative microorganism in mad cow disease?
Prions.
Why are prions unlike any other infectious disease?
They contain only protein and no nucleic acids
Infectious particle made of protein?
Prions are infectious proteins. Examples are the well known "mad cow disease" or bovine spongiform encephalopathy (BSE; affects cattle), scrapie (affects sheep), Creutzfeldt-Jacob disease, Kuru, Gerstmann-Sträussler-Scheinker syndrome, and Fatal familial insomnia. Variant Creutzfeldt-Jakob disease (vCJD) is the disease that occurs in humans when BSE proteins from cattle enter humans.
Can mad cow disease by identified by a gram stain?
Mad Cow Disease cannot be identified by a gram stain. Mad Cow Disease is caused by prions, incorrectly folded proteins. Gram staining is a way to separate bacteria into two groups - positive and negative - and cannot be used to identify prions, since prions are not bacteria.
What is the causes mad cow disease?
infectious proteins called prions
What is an aberrant protein?
aberrant proteins are prions which lead to infectious disease.
Can you give me all the information known about Prions?
Prions • Proteinaceous infectious agents (PrP) • Prions are misfolded proteins Diseases caused by prions: • spongiform encephalopothies • BSE (Bovine Spongiform Encephalopathy, aka Mad Cow Disease) • CJD (Creutzfeldt-Jakob disease) • kuru • scrapie in sheep Prions are only destroyed by: • incineration • autoclaving in 1N NaOH
Which flu is the worst mad cow disease or Swine Flu?
Mad cow Disease is not a flu. It is caused by different kinds of organisms called prions, not viruses. It is much more severe than swine flu since the infection is in the brain and central nervous systems of the cattle.
What is another name for prion disease?
A prion is a misfolded protein that is considered an infectious agent because they cause properly folded proteins to convert into the misfolded, prion form. In humans, prions cause Creutzfeldt-Jakob disease. In cattle, prions cause mad-cow disease.
