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What is an alternative reagent to ethanoic anhydride in the synthesis of aspirin from salicylic acid?
Synthesis of acetyl chloride via the reaction of acetic acid with sulphuric acid
What else can I help you with?
What are the impurity in aspirin synthesis?
The main impurties are probably the unreacted reactants. i.e salicylic acid and some acetic anhydride (ethanoic anhydride)
What are the compound names for salicylic acid and acetic anhydride?
Your question has the names right in it. Maybe it's the chemical formulas you want. In that case, salicylic acid is C7H6O3 and acetic anhydride is C4H6O3.
What is the equation for the oxidation of ethanoic anhydride by potassium permanganate?
Ethanoic anhydride can no longer be oxidized by any oxidizing agent.
How does ethanoic anhydride undergo dehydration?
Ethanoic anhydride cannot be dehydrated any further as it is already the dehydrated form of Ethanoic acid. You can remove water from Ethanoic acid by using Concentrated H2SO4.
Mechanism of aspirin synthesis?
Aspirin is generally produced by the following mechanism (starting from basic materials) Phenol --(NaOH, CO2, heat)--> Sodium Salicylate (+para isomer) --(H2SO4)--> Salicylic acid --(acetic anhydride)--> acetylsalicylic acid (Aspirin) Due to the myriad of organic reactions, there are multiple possibilities at each stage. However, the above is the most efficient and common way of synthesizing Aspirin. For example, the last reaction (esterification) may be accomplished by using an acyl halide instead of an anhydride (e.g. ethanoyl/acetic chloride instead of acetic anhydride). However, the acyl halide is more costly to synthesize and more unstable to handle.
What happen when ethanoic acid is heated with p2o5?
When ethanoic acid is heated with P2O5, it will undergo dehydration reaction to form acetic anhydride. The P2O5 serves as a dehydrating agent by removing water molecules from the ethanoic acid molecule, resulting in the formation of acetic anhydride.
Is ethanoic an-hydride soluble?
Yes ethanoic (acid) anhydride is soluble in WATER but at first it reacts (hydrolysis) heavily and exothermic with water.
What prodduct would you expect to be formed when a molecule of water is eliminated from ethanoic acid?
When ethanoic acid gets dehydrated, ethanoic anhydride is formed. The formula is (CH3 CO)2O.
What is the function of the condenser used in reflux apparatus in the preparation of aspirin?
upon heating, ethanoic anhydride turns into a gas. this would then leave the reflux apparatus. the role of the condenser is to condense this gaseous ethanoic anhydride back into a liquid, so that it will run back into the reacting mixture and will react with the 2-hydroxybenzoic acid to form aspirin. this will result in a higher yeild of aspirin.
An advantage for Ethanoic acid?
1. use as a solvent and laboratory reagent 2. use as a preservative 3. use for preparing white lead [2PbCo3.Pb(OH)2 4. use for preparation of acetone and acetic anhydride. 5. use for manufacturing of dyes, perfumes, plastics, rubber, etc.
How do you convert phenol to aspirin?
C6H5OH + CH3Cl -----(AlCl3)-----> C6H5OHCH3 + HCl phenol + chloromethane ----> 2-methylphenol C6H5OHCH3 -----(alkaline KMnO4, then acidify with HCl)-----> C6H5OHCOOH 2-methylphenol -----> 2-hydroxybenzenecarboxylic acid C6H5OHCOOH + (CH3CO)2O (ethanoic anhydride) -----(c.H2SO4 catalyst)-----> aspirin (C6H5OCOCH3COOH) + (ethanoic acid) CH3COOH
What is ethanol and ethanoic acid used for?
If you ever had vinegar on your salad, you used ethanoic acid. Ethanoic acid is more commonly known by its other name of acetic acid, and vinegar is most often a dilute (<10%) solution of acetic acid.
