An antifolate is any drug which inhibits the activity of folic acid.
Joan Colby Hill has written: 'Structural studies on antifolate drugs'
Stephen George Henry Pashley has written: 'Pharmacokinetics and metabolism of MZPES, a novel lipophilic antifolate'
Chemotherapy as a cancer treatment was first developed by Dr. Sidney Farber in the 1940s. Dr. Farber's work with antifolate drugs like aminopterin and methotrexate laid the foundation for modern chemotherapy treatments.