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What is an asparaginase?

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Bobo192

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10y ago
Updated: 8/21/2019

An asparaginase is an enzyme which catalyzes the hydrolysis of asparagine to aspartic acid, used in chemotherapy.

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10y ago

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What is pharmaceutical importance of asparaginase enzyme?

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Asparaginase is extracellular or intracellular protein?

It is either extracellular or intracellular protein. It depends on the type of micro organism employed in the production of L- Asparaginase. It is sometimes both Intracellular and extracellular.


You would like to convert 1000 IU of Asparaginase to mg?

"http://wiki.answers.com/Q/You_would_like_to_convert_1000_IU_of_Asparaginase_to_mg"


Is asparginase is active at room temperature?

Asparaginase is a drug that is stable for at least 48 hours at room temperature. If the drug?æis stored above or below recommended temperatures, the potency of the drug will be reduced.?æ


What drugs can interfere with a Triglycerides test?

Oral contraceptives, estrogen, and cholestyramine can increase triglyceride levels. Ascorbic acid (vitamin C), asparaginase (an enzyme), and various drugs used to treat high blood lipids, can decrease blood triglyceride levels.


Structure of L asparginase?

L-asparaginase is a tetrameric enzyme consisting of four identical subunits. Each subunit contains a zinc ion in the active site that plays a crucial role in catalyzing the reaction that converts asparagine to aspartic acid and ammonia. The enzyme also requires magnesium ions for stability and optimal activity.


What research has been done on reishi mushroom?

Amino acids; vegetable proteins; iron; thiamine (vitamin B1); riboflavin (vitamin B2); niacin; and vitamins B6, B12, and D2; lentinan; pepsin; trypsin; asparaginase; chitin; eritadenine; lentinacin; And more . . .


An example of hyperglycaemic drug?

danazol, glucocorticoids, thiazide diuretics, oral contraceptives, Beta2 agonist, nicotinic acid, pentamidine, somatropin, atypical antipsychotics. danazol, glucocorticoids, thiazide diuretics, oral contraceptives, Beta2 agonist, nicotinic acid, pentamidine, somatropin, atypical antipsychotics.


Triglyceride level?

DefinitionThe triglyceride level is a laboratory test to measure the amount of triglycerides in your blood. Triglycerides are a type of fat.Your body makes some triglycerides. Triglycerides also come from the food you eat. When you eat, your body uses carbohydrate calories for immediate energy. Leftover calories are turned into triglycerides and stored in fat cells for later use. If you eat more calories than your body needs, your triglyceride level may be high.See also:Low density lipoprotein testHigh density lipoprotein testHigh blood cholesterol and triglyceridesTotal cholesterol testAlternative NamesTriacylglycerol testHow the test is performedBlood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.How to prepare for the testYou should not eat for 8 to 12 hours before the test.Alcohol and certain drugs may affect test results. Make sure your doctor knows what medicines you take, including over-the-counter drugs and supplements. Your doctor may tell you to temporarily stop taking certain medicines. Never stop taking any medicine without first talking to your doctor.Drugs that can increase triglyceride measurements include beta blockers, cholestyramine, colestipol, estrogens, protease inhibitors, retinoids, certain antipsychotics, and birth control pills.Drugs that can decrease triglyceride measurements include ascorbic acid, asparaginase, clofibrate, fenofibrate, fish oil, gemfibrozil, nicotinic acid, and statin medications.How the test will feelWhen the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.Why the test is performedThe most important use of this test is to help estimate your LDL cholesterol. This test is also done to help determine your risk of developing heart disease. A high triglyceride level may lead to atherosclerosis, which increases your risk of heart attack and stroke. A high triglyceride level may also cause inflammation of your pancreas.Persons with a high triglyceride level often have other conditions such as diabetes and obesity that also increase the chances of developing heart disease.The triglyceride level is usually included in a lipid panel or coronary risk profile.Normal ValuesNormal: Less than 150 mg/dLBorderline High: 150 - 199 mg/dLHigh: 200 - 499 mg/dLVery High: 500 mg/dL or aboveWhat abnormal results meanHigh triglyceride levels may be due to:CirrhosisDiet low in protein and high in carbohydratesFamilial hyperlipoproteinemia (rare)HypothyroidismNephrotic syndromePancreatitisPoorly controlled diabetesLow triglyceride levels may be due to:Low fat dietHyperthyroidismMalabsorptionsyndromeMalnutritionAdditional conditions under which the test may be performed:Chylomicronemia syndromeHyperlipidemia; acquiredFamilial combined hyperlipidemiaFamilial dysbetalipoproteinemiaFamilial hypertriglyceridemiaFamilial lipoprotein lipase deficiencyNoninsulin-dependent diabetes (NIDD)Stroke secondary to atherosclerosisWhat the risks areVeins and arteries vary in size from one patient to another, and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others. Other risks may include:Excessive bleedingFainting or feeling light-headedHematoma (blood accumulating under the skin)Infection (a slight risk any time the skin is broken)Special considerationsPregnancy can interfere with test results.ReferencesExpert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001;285(19):2486-2497.Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation. 2004 Jul 13; 110(2):227-39.Semenkovich CF. Disorders of lipid metabolism. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 217.