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As a rule more than one presynaptic action potential is needed to fire the postsynaptic neuron or muscle so that the trigger to initiate an action potential are either many subthreshold local potentials from different sources or from the same neuron received within a short period of time. The first case is called spatial summation and the second case is called temporal summation. Whether a postsynaptic potential (another term for a local potential) is excitatory or inhibitory depends on what ion channels are affected by the transmitter released from the presynaptic vesicles.

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15y ago
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13y ago

Postsynaptic potentials (PSPs) are depolarizations/hyperpolarizations that increase the likelihood that a cell will have an action potential (AP).

PSPs are fast, graded responses and their signal travels passively through the neuron's membrane and are therefore decremental (getting weaker as it gets farther from the site of generation). In other words, these are the inputs to neuron that could make the neuron fire.

APs is what happens if enough PSPs sum up. This is the neuron firing. There is a massive but short reversal of the membrane potential. The signal travels actively down the axon (read about voltage-activated sodium and potassium channels), so the AP is not decremental and is an all-or-nothing response.

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Excitatory increases the likelihood of the cell firing an action potential. Inhibitory decreases the likelihood.

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Q: What is the difference between the way excitatory and inhibitory transmitters work?
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What is the function of a neurotransmitter?

NEUROTRANSMITTERS are the brain chemicals that communicate information throughout our brain and body. They relay signals between nerve cells, called "neurons." The brain uses neurotransmitters to tell your heart to beat, your lungs to breathe, and your stomach to digest. They can also affect mood, sleep, concentration, weight, and can cause adverse symptoms when they are out of balance. Neurotransmitter levels can be depleted many ways. As a matter of fact, it is estimated that 86% of Americans have suboptimal neurotransmitter levels. Stress, poor diet, neurotoxins, genetic predisposition, drug (prescription and recreational), alcohol and caffeine usage can cause these levels to be out of optimal range.There are two kinds of neurotransmitters - INHIBITORY and EXCITATORY. Excitatory neurotransmitters are not necessarily exciting - they are what stimulate the brain. Those that calm the brain and help create balance are called inhibitory. Inhibitory neurotransmitters balance mood and are easily depleted when the excitatory neurotransmitters are overactive.


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Related questions

What is the difference between EPSP and an IPSP?

An EPSP is an excitatory postsynaptic potential, which represent input coming from excitatory cells, whereas an inhibitory postsynaptic potential represents input driven by inhibitory presynaptic cells.


How can decision-making in the CNS result from the interaction between the activities of excitatory and inhibitory presynaptic neurons at synapses?

During decision-making, information is processed to choose between two or more alternatives. This involves the interaction of excitatory and inhibitory neurons. This process also involves excitatory and inhibitory neurotransmitters. The post-synaptic action potential is determined by the sum of all signals.


What is meant by summation at a synapse and how can the two ways it is accomplished be described?

Summation is the method in which signal transmission between neurons occurs. Summation occurs through excitatory neurotramitters and inhibitory neurotransmitters. Excitatory produces depolarization of the postsynaptic cell. Inhibitory mitigates the effects of an excutatory neurotransmitter. For more information visit the Related Link.


What is the difference between an excitatory synapse and an inhibitory synapse?

Synapses are junctions that allow a neuron to electrically or chemically transmit a signal to another cell. Synapses can either be excitatory or inhibitory. Inhibitory synapses decrease the likelihood of the firing action potential of a cell while excitatory synapses increase its likelihood. Excitatory synapses cause a positive action potential in neurons and cells. For example, in the neurotransmitter Acetylcholine (Ach), its binding to receptors opens up sodium channels and allows an influx of Na+ ions and reduces membrane potential which is referred to as Excitatory Postsynaptic potential(EPSP). An action potential is generated when the polarization of the postsynaptic membrane reaches threshold. ACh acts on nicotinic receptors which can be found at the neuromuscular junction of skeletal muscles, the parasympathetic nervous system, and the brain. It also acts on muscarinic receptors found at neuromuscular junctions of the smooth muscles, glands, and the sympathetic nervous system. Inhibitory synapses, on the other hand, cause the neurotransmitters in the postsynaptic membrane to depolarize. An example is the neurotransmitter Gamma Aminobutyric Acid (GABA). The binding of GABA to receptors increases the flow of chloride (CI-) ions in the postsynaptic cells raising its membrane potential and inhibiting it. The binding of GABA to receptors activates a second messenger opening potassium channels.


What is the function of a neurotransmitter?

NEUROTRANSMITTERS are the brain chemicals that communicate information throughout our brain and body. They relay signals between nerve cells, called "neurons." The brain uses neurotransmitters to tell your heart to beat, your lungs to breathe, and your stomach to digest. They can also affect mood, sleep, concentration, weight, and can cause adverse symptoms when they are out of balance. Neurotransmitter levels can be depleted many ways. As a matter of fact, it is estimated that 86% of Americans have suboptimal neurotransmitter levels. Stress, poor diet, neurotoxins, genetic predisposition, drug (prescription and recreational), alcohol and caffeine usage can cause these levels to be out of optimal range.There are two kinds of neurotransmitters - INHIBITORY and EXCITATORY. Excitatory neurotransmitters are not necessarily exciting - they are what stimulate the brain. Those that calm the brain and help create balance are called inhibitory. Inhibitory neurotransmitters balance mood and are easily depleted when the excitatory neurotransmitters are overactive.


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What are the main signal propagation?

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What are the 5 neurotransmitters of the brain and what are they responsible of?

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What are the main problems of signal propagative?

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