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Vesalius was faced with many difficulties, many people were against him and his work, one of these people was an english men named John Keys. Keys believed firmly in Galen's work and thought that Vesalius was wrong to disagree, for Keys, any mistakes in Galens work was due to translators, or copyists, and not by Galen himself.

In addition Vesalius was asked to carry out a dissection in Bologna, and he broke the rules.He ignored the professors and the old men, he began a lecture of his own and invited students to gather around to see and even touch when they were not supposed to. Vesalius then brought a skeleton into the lecture room, he showed his students how muscles move the bones and so on, however the professor disagreed with him and said that these are not the opinions of Galen.

Even Vesalius's old teacher, gunter von andernacht was against Vesalius and wrote the he should be punished by the emperor for the terrible things he was saying however Vesalius won! The emperor ignored Andernacht and appointed Vesalius as his physician.

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