Flumazenil (brand name Romazicon US, Anexate CA) is a benzodiazepine receptor antagonist that can be administered in the event of benzodiazepine overdose to stop or reverse their sedative effects.
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Romazicon/Roche (Flumazenil) is a specific benzodiazepine receptor antagonist indicated for the reversal of the CNS depressant effects of the benzodiazepines. It is contraindicated where multiple agents (ie: tricyclic antidepressants) have also been used concomitantly. Given that Flumazenil is a benzodiazepine receptor antagonist, it must be borne in mind that seizures may be invoked in individuals whom are physically dependent on benzodiazepines, and hence, it should not be used in this scenario unless absolutely warranted.
Flumazenil is a benzodiazepine antagonist given *as part of* a treatment for Ativan (and other benzodiazepines) overdose in *hospitalized* patients. Flumazenil itself has its own risks and these risks should be considered by the prescriber.
To reverse benzodiazepine (Valium, Xanax etc) overdose.
Flumazenil reverses the effects of benzodiazepine (BENZ-oh-dye-AYZ-e-peen) sedatives such as Valium, Versed, Xanax, Tranxene, and others. Benzodiazepines are sometimes used as sedatives before surgery or other medical procedures. Flumazenil is used to reverse benzodiazepine sedation to help you wake up after your medical procedure. Flumazenil is also used to treat benzodiazepine overdose in adults.
Flumazenil is sometimes used in the event of accidental benzodiazepine overdose.