Lucentis is an anti-VegF drug ranibizumab used to treat Wet AMD and macular edema associated with retinal vein occlusion (RVO). Ozurdex is a dexamethasone implant used to treat macular edema associated with retinal vein occlusion (RVO) as well as non-infectous posterior segment uveitis. For RVO, the two drugs work differently but Ozurdex is seen to last longer than Lucentis and therefore less frequent injections. Ask your doctor for more details and for which one is right for you.