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In simplest terms, an ion occurs when an atom has a different number of electrons than expected. Ions can be either positively or negatively charged. (If # of electrons goes up, then the charge becomes more negative, if the # of electrons goes down, the charge becomes more positive.)

Therefore theoretically a helium atom would have to either gain electrons (for a total of 3 or more electrons), or lose electrons (for a total of 1 or 0 electrons).

Speaking about the helium atom specifically, you won't see ions of helium as commonly as you would see ions of other atoms due to the very high ionization energy required for the 1st electron and the essentially nonexistent electroegativity(Pauling scale).

There are antiprotonic helium ions (where an antiproton orbits a helium nucleus). Refer to studies conducted 2005-2006 by CERN on anitprotons and antiprotonic helium.

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