Hypercelluar marrow, is when the marrow has an abnormal increase in cells present normally relating to leukocytes and their precuors. Common in acute myeloid leukaemia.
Hypercellular particles in a biopsy refer to an increased number of cells within a specific tissue sample, often indicating abnormal growth or proliferation. This finding can suggest various conditions, including inflammation, infection, or malignancy, depending on the context and the type of cells involved. The term highlights the density of cellular components relative to normal tissue, prompting further investigation to determine the underlying cause. Pathologists often assess these hypercellular areas for specific characteristics to aid in diagnosis.
Hypercellular bone marrow can be caused by conditions such as hematologic malignancies (e.g., leukemia, lymphoma), myeloproliferative disorders (e.g., polycythemia vera, essential thrombocythemia), bone marrow hyperplasia (e.g., recovery from anemia or infection), or infiltration by metastatic cancer cells. Further evaluation with bone marrow biopsy and additional testing is often needed to determine the underlying cause.
Hypercellular marrow refers to bone marrow that contains an increased number of hematopoietic (blood-forming) cells compared to normal levels. When it is described as "40 percent," it typically indicates that 40% of the marrow space is occupied by these cells, suggesting an active production of blood cells, which can be seen in conditions like anemia, infections, or certain blood disorders. This finding may warrant further investigation to determine the underlying cause and its clinical significance.