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What is intrinsic sphincter deficiency?

Updated: 10/25/2022
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GaleEncyofSurgery

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13y ago

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the sphincter muscles are unable to keep the bladder closed (intrinsic sphincter deficiency, ISD).

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Q: What is intrinsic sphincter deficiency?
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Why oral administration of vitamin B12 not effective as a treatment of pernicious anemia?

Pernicious anemia is due to a deficiency of a vitamin called intrinsic factor, which is normally produced by cells of the stomach. Intrinsic factor is required for the absorption of vitamin B12, so if intrinsic factor levels are insufficient, vitamin B12 will not be absorbed well. So administration of vitamin B12 will only help treat vitamin B12-deficiency anemia if vitamin B12 can be absorbed, and this can only happen if there are adequate levels of intrinsic factor to begin with. Patients with pernicious anemia do not have adequate intrinsic factor levels, so they will not be helped by vitamin B12 treatment since they can't absorb it well enough.


What sphincter is associated with the pancreas?

Sphincter of Oddi.


How does the muscle of the internal anal sphincter differ from that of the external anal sphincter?

The internal urethral sphincter an involuntary sphincter that keeps the urethra closed when urine is not being used. The external urethral sphincter is fashioned by skeletal muscles as the urethra passes thorugh the pelvic floor.This sphincter is voluntary controlled.


Do compound semiconductors behave as intrinsic semiconductors?

Intrinsic refers to the doping -- intrinsic semiconductors are not doped. Whether compound or not, if they are not doped they are intrinsic.


Is the Sphincter a voluntary muscle?

The anal sphincter and the bladder sphincter in potty trained children and in most other people whose spinal cords are intact or are not suffering from some diseases.

Related questions

What is Type III of stress incontinence?

Type III: Hypermobility of the urethra where the primary source of incontinence is the inability of the sphincter muscles to keep the bladder closed. This is due to weakness or deficiency in the intrinsic sphincter muscles


What condition is treated with retropubic suspension?

to correct incontinence.Incontinence is common when either the urethra lacks tautness and stability (genuine stress urine incontinence, SUI) and/or the sphincter muscles are unable to keep the bladder closed (intrinsic sphincter deficiency, ISD).


Why do you need intrinsic factor?

Intrinsic factor or gastric intrinsic factor is a protein produced by the stomach. It is used to absorb vitamin B12 in the small intestine. When there is a deficiency of the Intrinsic factor, there is a deficiency in the absorption of B12 into the body and this leads to pernicious anemia.


What are some causes of sphincter deficiency?

Sphincter deficiency can result directly from pelvic fracture; urethral reconstruction; prostate surgeries; spinal cord injury; neurogenic bladder conditions that include sphincter dysfunction; and some congential conditions.


What results from the hereditary lack of intrinsic factor?

Pernicious anemia (vitamin B 12 deficiency)


How pernicious anemia cause achlorhydria?

pernicious anemia is a vitamin B12 deficiency. Vitamin B12 requires Intrinsic Factor to be reabsorbed by the ileum. Intrinsic Factor is produced by parietal cells in stomach. If there is some damage or manipulation of parietal cells, which also produce HCl, there will be less of both intrinsic factor causing B12 deficiency and HCl causing achlorhydria.


Which clinical condition would occur if intrinsic factor was not produced by t he gastric glands?

A b-12 deficiency.


Why oral administration of vitamin B12 not effective as a treatment of pernicious anemia?

Pernicious anemia is due to a deficiency of a vitamin called intrinsic factor, which is normally produced by cells of the stomach. Intrinsic factor is required for the absorption of vitamin B12, so if intrinsic factor levels are insufficient, vitamin B12 will not be absorbed well. So administration of vitamin B12 will only help treat vitamin B12-deficiency anemia if vitamin B12 can be absorbed, and this can only happen if there are adequate levels of intrinsic factor to begin with. Patients with pernicious anemia do not have adequate intrinsic factor levels, so they will not be helped by vitamin B12 treatment since they can't absorb it well enough.


Where does the absorption of vitamin B12 occur?

The vitamin B12 is a very important nutrient; it lowers risk of stroke, heart disease, cancer, Parkinson's, and Alzheimer's disease. The vitamin begins to absorb in the mouth, in contrast to most nutrients.


The voluntary sphincter is the -----sphincter?

outer anal sphincter


Sphincter found between the esophagus and the stomach?

What is the function of the cardiac sphincter?


What stomach secretion is necessary for normal hemoglobin Production in RBC's?

Intrinsic factor is secreted by the parietal cells and is critical for absorption of B12. When the body attacks the parietal cells b12 deficiency results which is called "pernicious anemia."