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Its molecular shape is altered so the substrate cannot fit to its active site
Enzymes are proteins that help speed up the the rate of chemical reactions in the human body. Enzymes possess a specific shape and this shape fits into the substrate. When an enzyme becomes denatured, it loses its shape and thus it cannot function effectively. Enzymes may become denatured due to high temperatures or changes in the pH.
the active site would no longer fit into the substrate
Shape. When an enzyme is overheated the bonds between molecules that make up the enzyme breaks, this changes the shape of the enzyme's active site. And as the enzyme is highly specific and would only work on one substrate which fits its active site, the enzyme will be totally denatured and won't activate anymore if it loses its shape.
Its considered Denatured
Its molecular shape is altered so the substrate cannot fit to its active site
denatured
Enzymes are proteins that help speed up the the rate of chemical reactions in the human body. Enzymes possess a specific shape and this shape fits into the substrate. When an enzyme becomes denatured, it loses its shape and thus it cannot function effectively. Enzymes may become denatured due to high temperatures or changes in the pH.
the active site would no longer fit into the substrate
At a high ion concentration, the ion interfere with the bonds between the side groups of the amino acids making up the enzyme (which is a protein). This causes the enzyme to lose its shape, called denaturation. If the enzyme loses its shape, it can no longer accept and react substrate, so the rate of enzyme activity decreases.
When an enzyme is denatured the active site which allows it to catalyze reactions is destroyed, rendering the enzyme useless. This process is irreversible but the remains are recycled to form new enzymes.
Shape. When an enzyme is overheated the bonds between molecules that make up the enzyme breaks, this changes the shape of the enzyme's active site. And as the enzyme is highly specific and would only work on one substrate which fits its active site, the enzyme will be totally denatured and won't activate anymore if it loses its shape.
Its considered Denatured
enzyme require an optimum temperature and ph level to be active. temperature at which most enzymes are active is around 35-40 degree celcius. above this temperature the enzyme loses it globular structure and thus the substrate will not be able to bind with it. some enzymes are active in alkali ph while others are active in acidic temperature. but most of the enzymes are active in neutral ph and this helps to maintain its globular structure.
Enzymes are made up of proteins. At a high temperature, the polypeptide chains of the enzyme are unfolded hence it loses its specific 3D configuration and active site, and is denatured.
When this happens to a protein, it is said to denature.Denature is caused commonly by very high or low temperature,concentrated acids or bases.Denature by high temperature is irrevesible.
The Active Site. If the protein is denatured however, the active site loses shape and the substrates don't fit in the active site (subtrates are "put together" by the enzyme at the active site).