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In New York Harbor, just off the southern tip of Manhattan.
Wall Street is the financial capital.
There is no island right at the southern tip of Africa. Madagascar is a large island and also a nation to the east of Mozambique, but it is not at Africa's tip. You may be thinking of Madagascar. There are other island groups to the north and to the east of Madagascar.
Cuba
Sicily is located directly at the southern tip of Italy at the toe of the boot.
India
No, it is a research station located in Antarctica located on the southern tip of Ross Island
Sicily is an island located southwest of the Italian mainland. It is part of Italy.
New York Harbor is located at the tip of Lower Manhattan.
New York City is located at the southern tip of New York State. If you can find New York State on the map -- it's shaped like a misshapen triangle -- New York City is located at the bottom point of the triangle. Directly to the right of the southern tip of New York State, you can see a large island, which is Long Island. Two of New York City's boroughs -- Brooklyn and Queens -- are located on the western end of Long Island, and Manhattan is directly to the west of Brooklyn and Queens.
Acklins island is a long, narrow, hilly island. It is located in the southern Bahamas Archipelago or southern tip, just about 250 miles southeast of Nassau.
South Padre Island is a very long barrier island located in Texas, along the southern-most tip of the state. The town of South Padre is on the southern part of the island, and much of the rest of it is dedicated to wildlife preservation.