It is a tiny colourless disk found in the blood of the vertebrates that helps with clotting of the blood.
Platelettes.
you should give some choices. DO you mean in an infection? What are you talking about? Brain cells are the "first" to act. They give the commands to neurons to tell other cells to do things (actually, they tell whole body parts and body systems to do things "FIRST!") But maybe lymphocytes or T or B cells, if you are talking about infection. Maybe platelettes if you are talking about wounds (if blood needs to close off a "leak" somewhere) If you are talking about which jail cell "acts" first when someone new comes into a jail - It would be the one that wants to kill you, or make you their bit*h. Next time, give more information.
I had the symmetrical rash on the back of my knee which lasted for about a month. It turned out to be shingles. It didn't itch that much until I went through the healing stage on the last week. Then I couldn't scratch enough. The first three weeks however turned out to be painful to the touch, but the pattern looked pretty cool, I could count the dots both across and down, and they matched in number both ways. What I'm having a problem with now is random NON ITCHY red dots and blotches on my left arm. I have had it for a year now, and it never itches. Sometimes a dot would appear and the only way I know its there is because I have blood on my clothes. Once in a great while, one would surface and break the skin. Again, I have no other sympton that it was there except visually. On some occasions, I develop a cluster of blotches that form an interesting symmetrical shape, all within the same size and color. I went to a couple of doctors who told me different things. I had my blood drawn and tested for a full panel on my platelettes, colesterol, blood sugar, thyroid, diabetis, everything. No one can tell me anything at all that can be corroborated through pictures online etc.