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Preformulation is the characterization of the physical and chemical properties of a drug, especially a newly discovered drug entity, including its interactivities and responses to environmental challenges prerequisite to enabling a formulator to develop a suitable, stable and aesthetically appealing pharmaceutical product or dosage form in which the drug is stable and from which the drug is available within generally acceptable time limits, in order to be optimally effective when administered or taken.
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What is use of preformulation in pharmacy?
"It was in the 1960s that pharmaceutical companies began to do drug preformulation studies. These important studies look at all the physical and chemical makeup of a drug, all of the properties of those chemicals and the molecular makeup. These items are examined in order to foresee and make contingency plans for any problems likely to come up during the drug's development due to the specific ingredients and their properties." - content provided by Xcelience CEO, Derek Hennecke (See link below for more details on preformulation)
What is the Role of pH in drug formulation?
A low pH is an abundance of hydrogen ions, where a high pH is an abundance of hydroxide. Both are important components in the formation and stability of many chemicals. Therefore, having a particular pH level is important to make sure that the desired chemicals are formed and that unwanted products are minimised or not created. They may also be necessary to get the wanted dug formed efficiently or at all, depending on the reaction pathways which are possible and intended. There are also tests for pH solubility of components in the pharmaceuticals, and a pka determination test. A thermal analysis can give information about how the components of a compound react at different temperatures, and toxicology formulations look at all the different ways a product might be delivered to the consumer, such as through a solution or suspension, or through a gel or cream. Delivery in a capsule is another possibility that would be tested in a good screening. An independent formulation development company can give the most reliable and valuable analyses for preformulation testing. These companies will also carry the most weight during the testing and approval processes. With the help of an excellent laboratory providing such testing, a pharmaceutical company has a partner in developing the best compounds, analysis, and manufacturing, giving the best chance for a desired outcome in the final testing process.
Give me some examples of memorandum?
There should be more than one example.Your boss Mr.jamir has asked you for suggestion to increase employee productivity in your office.Your suggestion is a new seating arrangement which would bring supervisors closer to their employees(supervisors now are grouped together in a separate suit).In addition, your think that the typists should be moved to another room to reduce the noise level.You are attaching a plan of your proposed rearrangement.M E M O R A N D U MTO: Graduate Council MembersFROM: Dr. Jane DoeDepartment of Basic Pharmaceutical Sciences DATE:September 5, 2002 SUBJECT: ULM COURSE OFFERINGSAfter a review of the pharmaceutics curriculum in the Department of Basic Pharmaceutical Sciences, five new courses are being submitted for approval. These courses are: (1) Pharmaceutical Preformulation (PHAR 577), (2) Solid State Chemistry of Drugs (PHAR 578), (3) Dosage Form Design (PHAR 579), (4) Surface and Interfacial Phenomena (PHAR 583), and (5) Chemical Kinetics and Stability of Pharmaceuticals (PHAR 584). The proposed new course offering will address new principles and concepts in pharmaceutics as well as addressing existing deficiencies in our curriculum.Please find the enclosed information for each course: a New Graduate Course Application form, a syllabus, and a Request for New Course Number form.Your assistance in facilitating the approval of these proposed courses will be greatly appreciated. If you have any questions, please contact me.
