What is required for a person to have sickle cell disease?

It is an inherited (genetic) disease. You would need to inherit the gene for sickle cell from both parents in order for you to develop sickle cell. If you inherit the gene from ONE parent, one of your children could inherit that, but you would not develop sickle cell yourself.

Sickle Cell is genetic, so your parents would have had to pass the sickle cell trait to you.