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Diphtheria is caused by toxin-producing strains of the gram-positive bacillus Corynebacterium diphtheriae. There are four biotypes of the bacterium (gravis, mitis, intermedius, and belfanti), and each differs in the severity of disease it produces. Nontoxigenic strains are usually responsible for less severe cutaneous diphtheria.

The signs and symptoms of respiratory diphtheria are caused by the bacterium's ability to cause a localized inflammatory reaction of the cells lining the upper respiratory tract. In certain cases, the disease can become more severe and widespread, and it can involve other organs of the body as well.

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Q: What is responsible for diphtheria and influenza?
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