It looks as if the shortest route, as far as driving time is concerned, is to take interstate 80 east to interstate 65 south/70 east toward Columbus. Then you take exit 4A from 70 east to get to 3rd street in downtown Columbus
The shortest driving distance is 81.6 miles.
The shortest driving distance is 2,078 miles.
The shortest driving distance is 143 miles.
The shortest driving distance is 325 miles.
The shortest driving distance is 401 miles.
The shortest driving distance is 86.2 miles.
The shortest driving distance is 1,164 miles.
2471 miles is the shortest driving distance.
The driving distance from Columbus, Ohio to Ypsilanti, Michigan is 189 miles.The driving distance from Columbus, Michigan to Ypsilanti, Michigan is 81 miles.
The driving distance from Columbus, Ohio to Des Moines, Iowa is 647 miles via I-80 W per MapQuest. The driving time per MapQuest is 9 hours and 43 minutes.
The shortest driving distance is 897 miles.
The shortest driving distance is 407 miles.