"Is it that…?" is a literal English equivalent of the French phrase Est-ce qu'.
Specifically, the verb est means "(he/she/it) is." The masculine demonstrative pronoun ce means "it, this." The conjunction que* means "that."
The pronunciation will be "e-skuh" in French.
*The vowel e drops - and is replaced by an apostrophe - before a word which begins with a vowel.