On an envelope as part of the address:
Familie
When referring to a couple:
die ..... e.g. that's Mr and Mrs Bauer - das sind die Bauers
das Ehepaar e.g. that's Mr and Mrs Bauer - das ist das Ehepaar Bauer
Mr and Mrs = Familie
Frau und Mann is the translation in German. It is translated from English to German. German is mostly spoken in the European countries.
"Frau", the German word equivalent of "Mrs." in English. Because "Herr" is Mr., his spouse would be Mrs.: Frau.
"Mrs" (old English >mistress) is the equivalent "Frau" in German.
frau
Monsieur and madame.
Willkommen Herr and Frau Welkenbach.
Mr and Mrs
Mr and Mrs is correct or Mrs and Mr is correct
Mr. and Mrs. (ex. "Hello, Mr. and Mrs. Evans" instead of "Hello, Mrs. and Mr. Evans")
Mr. & Mrs. Smith
In the US it is normally Mr. and Mrs.