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What allele for the sickle cell trait is with the normal allele?
codominant
The allele for the sickle cell trait is what with the normal allele?
The allele for the sickle cell trait is codominant with the normal allele. This means that in individuals with both alleles present, both traits are expressed.
What are the pros for SICKLE CELL ANEMIA?
The pro of sickle cell hemoglobin is that if you have only one allele for sickle cell hemoglobin and the other allele is normal, then you are immune to malaria.
Can heterozygous for sickle cell have greater resistance?
Yes, individuals who are heterozygous for the sickle cell trait (having one normal hemoglobin allele and one sickle cell allele) can have greater resistance to malaria. The presence of the sickle cell allele provides some protection against the malaria parasite, as the altered shape of the red blood cells makes it less hospitable for the parasite to thrive. This selective advantage is particularly observed in regions where malaria is endemic, leading to a higher prevalence of the sickle cell trait in those populations.
What are the chances that these parents will have three children who are homozygous for normal red blood cells if the parents both have sickle cell trait?
If both parents have sickle cell trait, they each carry one normal allele (A) and one sickle cell allele (S). The possible genotypes for their children are AA (normal), AS (carrier), and SS (sickle cell disease), with a probability of 25% for each genotype. Therefore, the chance of having three children who are homozygous for normal red blood cells (AA) is ( (0.25)^3 ), which equals 1/64, or about 1.56%.
If malaria were eliminated how might the frequency of the sickle-cell allele change over time?
Since people with the sickle cell allele trait are resistent to malaria, if malaria were eliminated there would be no change in the frequncy of sickle cell allele. This is because the presense of malaria does not have an affect on patients with the sickle cell allele trait.
If sickle-cell anemia is so destructive why hasn't the sickle-cell allele been eliminated from the population?
It is important to note that sickle-cell anemia comes in two forms. The homozygous sickle-cell anemia and the heterozygous sickle-cell trait. The difference between the two is that sickle-cell anemia has a high rate death rate at a young age (20~), and the sickle-cell trait is nearly asymptomatic.In regions such as North America, sickle-cell anemia would be selected against and would eventually leave the gene pool. The sickle-cell trait on the other hand, has little effect on the fitness of the organism, and as such will remain in the gene pool.In malaria endemic regions such as sub-Sahara Africa, sickle-cell anemia provides very high levels of immunity to malaria and the sickle-cell trait provides a slightly lesser level of immunity. Both forms of sickle-cell will increase the organisms fitness and as such, it will remain in the gene pool. Further on, the sickle-cell trait has greater fitness than sickle-cell anemia, hence, the sickle-cell trait will be selected as the fittest allele.If s is the sickle-cell allele and S is a normal allele;The relative fitness in malaria endemic regions;Ss > ss > SSSickle-cell trait > Sickle-cell anemia > NormalThe relative fitness in non-malaria endemic regions;SS > Ss > ssNormal > Sickle-cell trait > Sickle-cell anemia
what if the father has sickle trait, does that mean the baby will have it?
If one parent has sickle cell trait and the other parent has the normal type of hemoglobin, there is a 50% (1 in 2) chance with EACH pregnancy that the baby will be born with sickle cell trait.
Which individuals have the greatest fitness in an area where malaria is common?
Individual homozygous for the sickle cell anemia allele
Does sickle cell disease require two allele or multiple alleles?
Sickle cell disease is an autosomal reccessive sexlinked trait so, a female msut have 2 recessive alleles to have the trait and a male needs only one allele (this is because there is no corresponding site for this allele on the Y chromosome. The female can be a carrier of the disorder with the defective allele on one X chromosome and a normal allele on the other X chromosome. Female carrriers can have a mixture of normal and abnormal redblood cells.
The genetic disorder sickle cell disease is an example of heterozygous dominance?
Sickle cell disease is an example of codominance, not heterozygous dominance. In individuals who are heterozygous for the sickle cell allele, they exhibit a milder form of the disease called sickle cell trait, which demonstrates codominance of the normal and mutant hemoglobin alleles.
How long are you expected to live with a sickle cell trait?
Sickle cell trait should have no problems and should have a normal life expectancy
