It depends what it is to be used for.
The Angus is a breed of cattle
no
No. Animals will continue to breed as long as there is other animals of their species to breed to. However, no animal can ever be "over-bred."
It is simply managing when you breed animals to produce offspring at certain times and what two animals breed together.
Horses can be big animals. They range in size depending on the breed. The largest breed is the Shire Horse.
Many hybrid animals cannot breed.
you have to breed them together
When you are culling you are doing so to improve the breed of the animal. Animals with inherent poor quality or health go. Animals that do not represent their breed go.
to get a new breed
the best breed is a Labrador
There are many breeders who can track an animal's hereditary background. These breeders pick which animals would be best to breed.
I don't think you can make them breed, but I'm experimenting with other animals, and I found that if the two animals have green speech bubbles with a family symbol in it they will breed. So far only rabbits will breed.