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  1. Take U.S. 17 SOUTH from Myrtle Beach to I-95 in Yemassee. Follow signs to I-95 SOUTH to SAVANNAH. To bypass CHARLESTON, take I-526 WEST.
  2. Take I-95 SOUTH to Savannah. To get to the HISTORIC DISTRICT and the city proper, get off at EXIT 8 off I-95 in Hardeeville, South Carolina. Turn left off the exit ramp, then follow U.S. 17 SOUTH to Savannah. You will be crossing into SAVANNAH, GEORGIA via the TALLMADGE MEM. BRIDGE.
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Q: What is the best driving route from Myrtle Beach to Savanna ga?
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