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Route-66 is the best driving route from Los Angeles to Ontario Canada
Fly
www.mapquest.com will provide the best route.
What is the most direct driving route from Nice France to Marseilles
Just go up Route 611.
When traveling it is important to know which route is best. To get from Vancouver to Calgary, the best route would be to take the Trans Canada Highway 1.
a road
Take I-64 EAST to I-81 NORTH in Virginia. Stay on I-81 NORTH.Take I-81 NORTH to I-66 EAST to FRONT ROYAL and WASHINGTON at EXIT 300.Take I-66 EAST to Washington.
The best driving route from Calais to the Czech Republic is one that avoids going through Brussels. It takes about 11 hours to drive the distance.
Personally I'd probably use the I-80 route.
I-5 South
If you want to avoid going even as close to the District as I-495, then your best option is probably I-76 to I-70 to I-81 to I-64 to I-264.