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The fastest route is Hwy 580 east then south and pick up I-5 south. The scenic route is 101 south which then turns east at Oxnard. Allow 5-6 hours of drive time and comfort stops. Distance:

The direct distance between Las Vegas, Nevada and San Francisco, California is 420 miles (676 km).

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โˆ™ 2007-11-25 08:05:31
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Q: What is the best route from San Francisco to Las Vegas?
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