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"Best" is a matter of personal preference. Some people prefer interstates. Take I-264 W to I-95 south in Emporia to I-795 south to I-40 east in Piney Grove. That goes right into Wilmington. If I were driving, I'd take 13 south off of I-264 and take 11 south to I-40. It's about the same amount of driving time and it's 40 miles shorter. Personally, I think taking a yacht would be "best."

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Q: What is the best route to take from Norfolk VA to Wilmington NC?
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