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The best route to take from San Diego to the Grand Canyon is staying on I-15 until you hit Barstow then, you will merge on to I-40, staying on I-40 until you hit highway 180. http://www.fodors.com/community/united-states/best-route-from-grand-canyon-to-san-diego.cfm

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Q: What is the best route to take from San Diego, California to the grand canyon?
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