Depends what you mean by biggest. If you mean most important, then I would think the wheel. If you mean big as in size, then probably something stupid and not even worth mentioning. first the wheel then writting then the microchip.
There are two: whether there is a need for their invention, and is their invention original.
la riata grande. it was one of the biggest invetion
The Quantum Theory.
the steam engine
George Washington Carver's greatest invention is peanut butter.
The Apple computer.
automobile
biggest deer ever?
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Myspace
NO
megalodon is the biggest great white ever known