According to fueleconomy.gov, the GS 350 is city 19, highway 26. However, there are several other GS models, 350 AWD, 450h, and 460 which may have differing MPGs.
The lexus SC430 has a city fuel consumption rating of 16 in the city and 22 on the highway for a combined total of 18 using premium gasoline in the car.
The EPA range estimate for the 2008 Lexus IS-350 is 307.8 mi. in the city, 427.5 mi. on the highway.
The EPA range estimate for the 2006 Lexus IS-250 is 307.8 mi. in the city, 444.6 mi. on the highway.
The EPA range estimate for the 2007 Lexus IS-250 is 307.8 mi. in the city, 444.6 mi. on the highway.
The EPA range estimate for the 2009 Lexus IS-250 is 307.8 mi. in the city, 444.6 mi. on the highway.
The EPA range estimate for the 2013 Lexus IS-350 is 324.9 mi. in the city, 461.7 mi. on the highway.
The EPA range estimate for the 2011 Lexus IS-350 is 342.0 mi. in the city, 461.7 mi. on the highway.
The EPA range estimate for the 2012 Lexus LFA is 212.3 mi. in the city, 308.8 mi. on the highway.
The EPA range estimate for the 2008 Lexus IS-250 is 307.8 mi. in the city, 444.6 mi. on the highway.
The EPA range estimate for the 2013 Lexus IS-250 is 359.1 mi. in the city, 513.0 mi. on the highway.
The EPA range estimate for the 2011 Lexus IS-250 is 324.9 mi. in the city, 461.7 mi. on the highway.
The EPA range estimate for the 2006 Lexus IS-350 is 324.9 mi. in the city, 444.6 mi. on the highway.