What is the closest subway to 121 Houston St Manhattan?

Answer 1

There is no "121 Houston Street." There is a 121 East Houston Street and a 121 West Houston Street.

The closest subway station to 121 East Houston Street (at 2nd Avenue/Chrystie Street) is the F train (of the B-D-F-M, the orange line) to 2nd Avenue-Houston Street.

The closest subway stations to 121 West Houston Street are the C or E trains (of the A-C-E, the blue line) to Spring Street (at 6th Avenue) or the 1 train (of the 1-2-3, the red line) to Houston Street (at Varick Street).

Coming from either station, you'd walk up to Houston Street and then east to 121 West Houston Street. Spring Street is a couple blocks south of Houston, and the Houston Street Station on the 1 train is actually on Varick Street between King and Houston Streets.