0
What is the definitions of upstream versus downstream processes in bio-pharmaceutical development?
Wiki User
∙ 12y ago
as the name suggests upstream processing is what happens upstream i.e. before fermentation and is basically where you get your raw materials and put them into a reactor for fermentation. downstream is what happens after fermentation and is where you separate the cells from the fermentation broth by concentrating, purifying and viral filtering the broth to leave your product e.g. your protein therapeutic.
Wiki User
∙ 12y ago
Upstream processes in biopharmaceutical development refer to activities that involve the cultivation and manipulation of living cells or organisms. This includes processes like cell culture, fermentation, and genetic engineering to produce the desired therapeutic molecule.
Downstream processes, on the other hand, are involved in the purification, separation, and isolation of the therapeutic molecule from the complex mixture of other components produced during upstream processes. This includes techniques like chromatography, filtration, and extraction to obtain a highly pure and concentrated form of the final product.
Add your answer:
Earn +20 pts
What are the definitions of cellular transport processes?
Two main categories are active and passive transport.
What is the role of cytoplasm in development?
The cytoplasm is the site where most cellular activities occur, such as many metabolic pathways like glycolysis, and processes such as cell division.
Changes in the gene are referred to as?
As a gene changes within a life span, it is known as the genetic process. Genetic processes work together with an organism's environment to influence development and behavior.
How does a chromosome control cell processes?
A chromosome controls cell processes by biological processes such as mitosis and meiosis. These cell processes are what direct cell processes such as cell growth and division.
When scientists study natural processes they use to state observations about the processes and they use to state how or why the processes occur?
descriptions; explanation
What is a repository for definitions of data processes data flows data stores and data elements.?
A data dictionary is a repository that contains definitions of data processes, data flows, data stores, and data elements used in an organization. It helps to provide a common understanding of data terminologies and structures within a dataset or system. Data dictionaries are often used to maintain consistency and clarity in data management and analysis processes.
What does upstream and downstream mean in business?
Upstream and downstream refers to the supply chain of an industry. For example, if you're looking at a distribution plant then the manufacture would be downstream and the retailer would be upstream. Events or processes that happen before whatever is being looked at is downstream and whatever happens after is upstream.
Definitions about atoms?
An atom is the smallest chemical entity indivisible in chemical processes.
What are the definitions of cellular transport processes?
Two main categories are active and passive transport.
A company's organization and processes for distributing and delivering products to its final customers is called what?
the downstream portion of the supply chain
Which of these statements is trueCareer development and advancement are processes that will ultimately lead to a supervisory position?
Career development and advancement are ongoing processes that never end.
How people processes and take-in information?
The answer to this would be cognitive development.
What does IDP and development processes connect to?
Annual performance appraisal
What are the process of modernization?
The 5 sub processes of modernization are Technological development, Agricultural development, Urbanization, Industrialization, and Telecommunications.
What is the correct definitions of metabolism?
The processes taking place in the cells of a living body which extract, store, and use energy.-APEx'
What are the main processes of human development?
1. Biological2. Cognitive3. Socioemotional
What are biomarkers?
the National Institutes of Health Biomarkers Definitions Working Group defined a biomarker as "a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention."
