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The active ingredient in both pills is the same (Cetirizine). The difference between hydrochloride and dihydrochloride is the difference between the non active ingredients in the pills that are added to the drug so that there is enough bulk to make a pill. The above 'advice' is simply rubbish. Any (old Skool) A-Level chemistry student knows the difference between 'hydrochloride' and 'di-hydrochloride': Not the same molecule.However, in layman's terms: cetirizine di-hydrochloride is the real thing and is less likely to make you drowsy. Cetirizine hydrochloride is a copycat molecule to work around patent laws.From personal experience, cetirizine hydrochloride makes me drowsy, whereas cetirizine di-hydrochloride does not. :-)

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15y ago
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Ian Cockayne

Lvl 1
2y ago
Question: apparently the dihydrochloride has added lactose, will this affect people with lactose intolerance?
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13y ago

Diphenhydramine citrate gets quicker into your bloodstream than diphenhydramine hci. Citrate is used in advil people, while hci is used in benadryl

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Q: What is the difference between Cetirizine hydrochloride and Cetirizine dihydrochloride?
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Can you drink alcohol with Levocetirizine dihydrochloride?

Nothing... I take cetirizine hydrochloride myself - prescribed to alleviate hay fever. To quote the information leaflet from the box the tablets came in... "No significant interactions have been observed between alcohol and cetirizine at the recommended doses. "


What is the difference between avil and cetirizine?

The active ingredient in Cetirizine is Cetirizine hydrochloride. The active ingredient in Avil is pheniramine maleate. Both are used to treat symptoms of allergies. You should ask your pharmacist to confirm this information.


What is the difference between cetirizine and hydroxyzine?

Cetirizine has active ingredients of cetirizine hydrochloride. It is used in multiple allergies, idiopathic urticaria, oedema mucosal, rhinitis seasonal, blood pressure abnormal, rhinitis allergic.Hydroxyzine hcl has active ingredients of hydroxyzine hydrochloride. It is used in prophylaxis of nausea and vomiting, rash, depression, prurigo, rash erythematous, nausea.


What is the difference between Betahistine dihydrochloride and Betahistine mesylate?

The only real difference is the salt from which the medicine is derived. Betahistine dihydrochloride comes from a dihydrochloride salt, and mesilate comes from a mesilate salt.


What is the difference between acetyl l carnitine hydrochloride and acetyl l carnitine?

The mechanism for absorption is improved in the hydrochloride version, but I could be mistaken.


What is the difference between benzocaine and benzocaine hydrochloride?

benzocaine hydrochloride readily dissolves in water and bezocaine is only very slightly soluable in cold water


What is the difference between Amantadine and Amantadine hydrochloride?

Actually they are the same substance. A chloride ion is introduced to amantadine to become amantadine hydrochloride. This will be helpful to increase the solubility of amantadine. Most drugs are absorbed faster by the body if they are salts, especially hydrochloride salts and sulfate salts


Can you take Zyrtec with phentermine?

There are no known interactions between Zyrtec (cetirizine) and phentermine.


IS there a difference between Oxycontin hcl 5mg and oxycodone ir 5mg?

Yes Oxycontin hydrochloride is a time released tablet and oxycodone ir is an instant release tablet.


Can you take cetirizine while on antibiotics?

There are no interactions between any antibiotics that I can think of and cetirizine however there are many types of antibiotics out there so something specific would give a better certainty to any answer you'll receive.


What is the difference between Betahistine hydrochloride and Betahistine dihydrochloride?

BetahistineBetahistine hydrochloride is the generic name for the anti vertigo drug SERC. It was first registered in Europe in 1970 for the treatment of Ménière's disease. It is commonly prescribed for people who have balance disorders or to alleviate the vertigo symptoms associated with Ménière's disease.Betahistine is available in 8mg or 16mg tablets taken 3 times daily. Doses may be adjusted to between 24-48mg a day as needed. It is contraindicated for people with peptic stomach ulcers or tumours of the adrenal gland. People with bronchial asthma should be closely monitored.Chemistry and PharmacokineticsBetahistine chemically is 2-[2-(methylamino) ethyl] pyridine, and is formulated as the dihydrochloride salt. Is is as close resembling between the structures of betahistine and histamine.Betahistine comes in a tablet form and should be taken orally. It is rapidly and completely absorbed from its tablet form. The mean plasma half-life is 3-4 hours, and excretion is virtually complete in the urine within 24 hours. Plasma protein binding is very low.The metabolism of betahistine produced two inactive metabolites, pyriylacetic acid and 2-(2-aminoethyl) pyridine.


What is the difference between phentermine and phentermine hcl?

Phentermine hcl is short for phentermine hydrochloride, the medically recognized name for the anorexiant drug phentermine. Phentermine Resin is a brand name for one of the manufacturers.