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Well first of all horses are much bigger than mice so that's one answer, also if you were to sit and try to ride a mouse its little skeletal body would most likely break if an average human adult were to sit on it, But with most horse body's (14 in. to 18 in.) you would not break it because the horses body has more bones and muscles to help the bones be strong so you wouldn't break it.

I hope I answered your question.

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