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The difference is that granular leukocytes have granules in their cytoplasm while non-granular do not. Also granular leukocytes, such as neutrophils, eosinophils, and basophils respond to non-specific immunity and their main job is to digest pathogens. The non-granular leukocytes include lymphocytes and monocytes and they are part of the specific immune response of the body. The are called non-granular because their cytoplasm is clear and does not contain granules that show up with the addition of stain or dyes.

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