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Depends what you mean. There can be a hormonal issue, such as excessive GH secretion which will increase overall growth of the skeletomuscular system. Or no negative feedback of the LH receptors by testosterone causing hyper secretion of testosterone.

Duchenne's Muscular Dystrophy caused pseudohypertrophy of the calf muscles by replacing muscle fibers with fat and fibrous connective tissue, giving the appearance of larger more muscular calves.

But I suspect you're referring to the genetic defect in the Myostatin Gene (MSTN) that is found in certain breeds of cattle and dogs.

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Q: What is the disease that makes your muscles grow?
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