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Memphis, TN. From there you can take the City of New Orleans north to Carbondale or Chicago or south to New Orleans.
The only train to Tennessee from Chicago is the City of New Orleans. It is 442 miles to Newbern-Dyersburg and 528 miles to Memphis. It takes almost 8 hours to get to Newbern and 10 1/2 hours to get to Memphis.
Unfortunately, there is no Amtrak train service to Nashville. The old Union Station is now a Wyndham hotel and that is available for viewing. The closest Amtrak station is in Newburn, TN. From there you can take the City Of New Orleans north to Carbondale and Chicago or south to Memphis or New Orleans.
I would drive due to you can leave when you want and you can control where you go no flight delays or anything like that.
1.435 m.
736
parey
There has been no passenger train service in Phoenix Arizona from anywhere to anywhere since 1995.
7072.64 miles
800 KMS/ 12 hours by train
There is no direct train service from Memphis to Knoxville. Amtrak does not operate a route between these two cities. Travelers typically rely on alternative modes of transportation, such as bus services or driving. For train travel, one would need to find connections through other cities.
On bus, it takes seven hours and 38 minutes to get from New Orleans, LA to Panama City, FL. Currently there is no train services between these two cities.