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865 miles taking this route:

  1. Take U.S. 501 NORTH (towards CONWAY), from Myrtle Beach, to U.S. 378 WEST in Conway.
  2. Take U.S. 378 WEST to I-95 SOUTH to SAVANNAH.
  3. Take I-95 SOUTH to FL-70 OKEECHOBEE RD (to Florida's TURNPIKE) off EXIT 129 in FLORIDA. Follow signs off the exit ramp to the TURNPIKE, and then you will take the TURNPIKE (toll) - SOUTH towards KEY WEST. To bypass JACKSONVILLE, FL, take I-295 EAST BELTWAY (EXIT 362A off I-95 in FLORIDA to get onto I-295 EAST BELTWAY ; EXIT 61A off I-295 to continue on I-95 SOUTH to Daytona Beach).
  4. Take the TURNPIKE - SOUTH to U.S. 1 SOUTH to KEY WEST at END - TURNPIKE in Homestead.
  5. Take U.S. 1 SOUTH to Key West.
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Q: What is the distance from myrtle beach South Carolina to key west?
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