It is 392.96 miles via I-25.
santa fe
Denver CO to Santa Fe NM is 285 miles in a straight line.
About 400 miles.
distance from denver to santa fe is about 400 miles
Both are higher them Denver with Santa Fe at 7,260 feet and Albuquerque at 5,312 feet above sea level.
Well it's about 394.89 miles.
Urban Lights
It is 392.96 miles via I-25.
6 hours
Santa Fe Municipal Airport is located ten miles southwest of Santa Fe, New Mexico. American Eagles has flights to/from Phoenix and Dallas/Fort Worth. United Express has flights to/from Denver.
Denver to Santa Fe is closer to 300 than it is to 500 or 800 miles. The driving distance is 392 miles per Map Quest.
Travelling north from Santa Fe, New Mexico you would reach Denver, Colorado.