What is the driving distance from Greenville to Spartanburg SC?

Answer 1

http://gosoutheast.about.com/od/tripplanningmaps/ss/mileage_to_nc.htm
should answer your question.
Understand the following from a trucker: Expect to drive no more than 8 hours a day & overnight, either in a tent or a motel.
If you are tired, TAKE A NAP! If you drink, do it before you sleep, not while you drive.
Beware rest stops & the people you'll find there.
Bring along a portapottie, a cooler with ice & a cooker for food & coffee.
Truck stop food will only lighten your wallet, heavy your body & ruin your health.
Stay aware. Be polite & considerate on the road.
Drive 65 to save LOTS of gas, but when fast trucks pass you, blink your headlights twice to let them know they are safe to come back to the right lane. With two-wheelers, just blink once, since most of them don't know the code.
Watch out for what truckers call "Alligators," that is, ripped apart tires you'll come across suddenly. They call them such since their wire parts have a way to reach up & grab a brake line and rip it apart.
Report such when you see a road so littered.
Know that the Red Chinese have taken over our tire companies, so that's why we have that problem across the nation.
Have a safe drive. ALWAYS assume that the other drivers on the road are out to hit you. Only then will you "Arrive Alive."