just under 5 hours
Google Maps estimates the driving time as 4 hours and 52 minutes.
Google Maps estimates the driving time as 5 hours and 12 miles and give the road distance as 248 miles.
The driving distance between Naples, FL and Key Largo, FL is approximately 150 miles. The driving time would be approximately 3 hours if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work and rush hour traffic in urban areas.)
6 hour
270 miles
MapQuest estimates the driving time as 7 hours and 29 minutes.
The driving distance is about 160 road miles - roughly 3 hours of driving time.
271 miles taking this route:Take U.S. 1 NORTH from Key West to Florida's TURNPIKE NORTH in Homestead.Take the TURNPIKE NORTH to I-75 NORTH to NAPLES at EXIT 5.Take I-75 NORTH to Naples.
MapQuest estimates the driving time as 3 hours and 33 minutes.
Google Maps estimates the driving time as 3 hours and 34 minutes.
5 1/4 hours
The distance is 248 road miles.