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The 1953 Nature paper by James Watson and Francis Crick stated that each base pair (purine-pyrimidine pair, A-T and C-G) was held together by two hydrogen bonds.

It is now established that, while this is true for adenine-thymine (A-T), the cytosine-guanine (C-G) pairing involves three hydrogen bonds.

For a reproduction of the original paper, see:

http://www.nature.com/nature/dna50/archive.html

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16y ago

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