Stalingrad
There may be several ways of answering this question. For instance, it could be argued that the destruction of the Graf Spee in 1939 was Germany's first defeat. I would say that Germany's first significant defeat was at Stalingrad in early 1943.
The Nazi defeat at Kursk was the most important event in 1943.
February 1943
2 February 1943
2 February 1943
February 2nd 1943.
The first in 1943 was Franklin Delano Roosevelt
1943 - Georgia 9, UCLA 0
1943 Georgia-9 UCLA-0
1943 1943
The first in 1943 was Franklin Delano Roosevelt
Invading Japaneses- held island in the pacific