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What is the difference between the intrinsic and extrinsic pathways?
The intrinsic pathway of blood coagulation is initiated within the bloodstream by damage to the blood vessel, while the extrinsic pathway is initiated outside the bloodstream by tissue factor released from damaged tissues. Both pathways ultimately converge to activate factor X and lead to the formation of a blood clot.
Where is thromboplastin produced?
Thromboplastin, also known as tissue factor, is produced by subendothelial cells in blood vessel walls and by blood cells called monocytes and macrophages. Upon injury to a blood vessel, thromboplastin is exposed and initiates the extrinsic pathway of blood coagulation.
Are they three clotting pathways?
The coagulation cascade is classically divided into three pathways. The tissue factor (formerly known as the extrinsic) and the contact activation (formerly known as the intrinsic) pathways both activate the final common pathway of factor X, thrombin and fibrin.
Which of the following represents a difference between extrinsic and intrinsic blood clotting pathways?
An important difference between the extrinsic and intrinsic blood clotting pathways is the way they are initiated. The extrinsic pathway is activated by external trauma that exposes tissue factor, while the intrinsic pathway is triggered by factors within the bloodstream, such as collagen or platelets. Additionally, the extrinsic pathway is faster and primarily involved in the initial response to injury, while the intrinsic pathway is more complex and amplifies the clotting process.
Would a hemophiliac have an above or below normal coagulation time?
A hemophiliac is someone with uncontrolable bleeding. Hence the definiont, then the person would have a below normal coagulation time.
What Coagulation pathway is activated by factors within the bloodstream?
Extrinsic
In hematology what is PT and PTT?
Prothrombin time (PT) and partial thromboplastin time (PTT) tests are used to evaluate the extrinsic coagulation system
What do the medical abbreviations pt and ptt mean?
Prothrombin time (PT) and partial thromboplastin time (PTT) are tests that are used to evaluate the extrinsic coagulation system.
What are the steps of Coagulation pathway?
Blood coagulation can occur either through an intrinsic or extrinsic pathway. The first step in either pathway begins with the production of Factor X,which marks the common pathway of coagulation.
What is the humoral coagulation system?
The humoral coagulation system refers to the protein coagulation factor component.
What test measures the coagulation properties of blood?
The prothrombin time (PT) test measures how long it takes for blood to clot. This test evaluates the coagulation factors involved in the extrinsic pathway.
What are the functional advantages of the shortcut of the extrinsic pathway and of the multiple steps of the intrinsic pathway?
The extrinsic pathway shortcut allows for a rapid response to tissue injury by activating factor X directly, leading to a quicker initiation of the coagulation cascade. The multiple steps of the intrinsic pathway provide amplification of the coagulation response, resulting in a more robust clot formation and greater sensitivity to stimuli.
In what general way do the intrinsic and extrinsic mechanisms of clotting differ?
extrinsic pathway of coagulation the mechanism that produces fibrin following tissue injury, beginning with formation of an activated complex between tissue factor and factor VII and leading to activation of factor X, inducing the reactions of the common pathway of coagulation.intrinsic pathway of coagulation a sequence of reactions leading to fibrin formation, beginning with the contact activation of factor XII, and resulting in the activation of factor X to initiate the common pathway of coagulation.
Formation of thromboplastin?
Thromboplastin, also known as tissue factor, is released from damaged tissues or activated platelets during blood vessel injury. It initiates the extrinsic pathway of the coagulation cascade by forming a complex with coagulation factor VII, triggering the cascade that ultimately leads to the formation of a blood clot.
Is pf3 a pivotal molecule associated with the external surfaces of aggregated platelets and is involved in the intrinsic and extrinsic mechanisms of blood clotting?
No, PF3 is not a pivotal molecule associated with the external surfaces of aggregated platelets. It is a protein that plays a role in blood clotting by enhancing the activity of coagulation factors in the intrinsic pathway of blood coagulation.
What is the difference between the intrinsic and extrinsic pathways?
The intrinsic pathway of blood coagulation is initiated within the bloodstream by damage to the blood vessel, while the extrinsic pathway is initiated outside the bloodstream by tissue factor released from damaged tissues. Both pathways ultimately converge to activate factor X and lead to the formation of a blood clot.
What type of regulation results from the activites of the endocrine and the nervous system?
Extrinsic regulation
