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There is no ONE general guideline for predicting solubility. There are, however, a list of rules which can be consulted to predict the solubility of most compounds. One example of these rules can be found at the Chemwiki site.


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What is a common guideline for predicting solubility?

A common guideline for predicting solubility is "like dissolves like," which means that substances with similar polarities are more likely to dissolve in each other. For example, polar substances tend to dissolve in other polar substances, while nonpolar substances tend to dissolve in other nonpolar substances.


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