Well that depends on what kind of griffin you're talking about. If you mean a normal griffin, it can usually be killed by beheading, any type of fatal wound by a weapon, drowning (that's very hard), burning (that's very hard too), etc.
Traditionally in most legends, griffins are not assigned any special powers or magical properties that would make them any different from the animals they are composed of and so they can be killed by conventional means, just like any other animal.
depends what griffin your talking about
griffin
Spikes of gold
Griffins are never referred to in the Bible .
Other griffins. There is no mythological ancestor in fable.
Vancouver Griffins was created in 2000.
Griffins are mythical, NOT a real animal.
London Griffins was created in 2005.
Baby griffins are called chicks.
No. Griffins are a magical beast of considerable power. You would have no control over it.
Grey Griffins was created in 2006-03.
The Griffins have three kids: Chris, Meg, and Stewie
Father Griffins GAA was created in 1948.
Grand Rapids Griffins was created in 1996.